This fact sheet describes ways to reduce the risks of taking methadone for pain relief or medication-assisted treatment of opioid use disorders. It lists methadone side effects that require emergency attention and offers resources for additional information.

This brochure describes the use of methadone in medication-assisted treatment of heroin and other opioids, including narcotic pain medicines. It describes how to use methadone safely, the dangers of methadone overdose, and life-threatening methadone side effects.